Optimization of Brain and Head & Neck Radiotherapy

Daniëlle BP Eekers

The aim of this thesis is to further optimise radiation therapy of Brain and Head & Neck cancer by reducing the dose to the healthy surrounding tissue, so called organs at risk (OARs), leading to a reduction in side effects.

Different treatment techniques for photon and particle (e.g. proton) therapy are compared for multiple tumour sites. Furthermore, tools for consistent contouring and dose prescription are presented in close collaboration with the European Particle Therapy Network (EPTN).

 

EPTN consensus-based guideline for the tolerance dose per fraction of organs at risk in the brain

Daniëlle BP Eekers, Maarten Lambrecht, Petra De Witt Nyström, Ans Swinnen, Frederik WR Wesseling, Erik Roelofs, Esther GC Troost

 

EPTN consensus-based guideline for the tolerance dose per fraction of organs at risk in the brain

In collaboration with the European Particle Therapy Network, a consensus table of tolerance doses for Organs at Risk in the brain was created. These values were all defined as a near maximum EQD2 values. Using the linear quadratic formula the doses are recalculated depending on the number of fractions.

 

Please site this table as follows:

Eekers D, Lambrecht M, Nyström PDW, Swinnen A, Wesseling FWR, Roelofs E, Troost EG
EPTN consensus-based guideline for the tolerance dose per fraction of organs at risk in the brain
CancerData, 2018; doi:10.17195/candat.2018.01.1

EPTN International Neurological Contouring Atlas

Daniëlle Eekers, Lieke In T Ven, Erik Roelofs, Alida Postma, Esther G Troost


Eekers et al. have published an international neurological atlas for contouring of organs at risk in consensus with the European Particle Therapy Network (EPTN). The purpose of this consensus atlas is to decrease inter- and intra-observer variability in delineating OARs relevant for neuro-oncology. We propose this atlas is used in photon and particle therapy in order to derive consistent dosimetric data. When required this atlas will be updated according to new insights.

Included are all OARs known to be relevant for radiation-induced toxicity in neuro-oncology: brain, brainstem, cochlea, vestibulum & semicircular canals, cornea, lens, retina, lacrimal gland, optic nerve, chiasm, pituitary, hippocampus and skin. A new OAR relevant for neuro-cognition, the posterior cerebellum is also included.

Three-dimensional delineation of the fifteen consensus OARs for neuro-oncology are shown on CT and 3 Tesla (3T) MR images (slice thickness 1 mm with intravenous contrast agent). All are presented in transversal, sagittal and coronal view.


Please cite this Atlas as follows:

Eekers D, In ’t Ven L, Roelofs E, Postma A, Troost EG. 
EPTN International Neurological Contouring Atlas 
CancerData, 2017. doi:10.17195/candat.2017.08.1

 

Data

At Maastro Clinic, we strongly believe in the Computer Assisted Theragnostics (CAT) concept. By creating a shared database with medical imaging and characteristics in cancer patients, tumours and treatments we can greatly improve the ability to learn and predict the outcome of individual treatments within the coming years. Furthermore, it will ease and speed up the administration of patients for clinical trials and enhance the trial analysis.