Sharing data for cancer research
EPTN International Neurological Contouring Atlas (INCA) instruction videos
Please site this set of instructions as follows:
Hofstede D, Di Perri D, Roelofs E, Postma A, Troost EG, Eekers DBP EPTN International Neurological Contouring Atlas (INCA) instruction videos CancerData, 2022; doi:10.17195/candat.2022.02.1
EPTN consensus-based toxicity scoring standard for the follow-up of adult brain and base of skull tumours after radiotherapy
De Roeck et al. have published a guideline for consistent toxicity scoring and follow-up in adult brain tumour patients in consensus with the European Particle Therapy Network (EPTN). The purpose of this framework is to enable the collection of uniform toxicity data of brain tumour patients treated with photon and particle therapy. This will facilitate collaboration and further propel the research field of radiation-induced toxicities relevant for these patients.
Please site this table as follows:
Laurien De Roeck, Hiska L van der Weide, Daniëlle BP Eekers, Erik Roelofs, Esther GC Troost, Maarten Lambrecht EPTN consensus-based toxicity scoring standard for the follow-up of adult brain and base of skull tumours after radiotherapy CancerData, 2021; doi:10.17195/candat.2021.09.1
EPTN International Neurological Contouring Atlas - 2021 Update
Eekers et al. have published an international neurological atlas for contouring of organs at risk in consensus with the European Particle Therapy Network (EPTN) in 2018 and an update in 2021. The purpose of this consensus atlas is to decrease inter- and intra-observer variability in delineating OARs relevant for neuro-oncology.
Included are all OARs known to be relevant for radiation-induced toxicity in neuro-oncology: brain, brainstem (midbrain, pons, medulla oblongata), chiasm, cerebellum (anterior & posterior), cochlea, cornea, hippocampus (anterior & posterior), hypothalamus, lens, lacrimal gland, optic nerve, pituitary, skin, and vestibular & semicircular canals. To further facilitate research on cognition, vision and radiological changes after irradiation of the brain, potential clinically-relevant OARs are included: amygdala, caudate nucleus, cerebellum (anterior & posterior), corpus callosum, fornix, macula, optic tract, orbitofrontal cortex, periventricular space (PVS), pineal gland, and thalamus.
We propose this atlas is used in photon and particle therapy in order to derive consistent dosimetric data. When required this atlas will be updated according to new insights.
Three-dimensional delineation of the 25 consensus OARs for neuro-oncology are shown on CT (WW/WL 120/40, 3000/600), 3T MR images, (T1Gd, T2FLAIR 1mm) and 7T MR (MP2RAGE 0.7 mm). All are presented in transversal, sagittal and coronal view.
Please cite this Atlas as follows:
Eekers D, Di Perri D, Roelofs E, Postma A, Troost EG. EPTN International Neurological Contouring Atlas - 2021 Update CancerData, 2021. doi:10.17195/candat.2021.02.1
Optimization of Brain and Head & Neck Radiotherapy
The aim of this thesis is to further optimise radiation therapy of Brain and Head & Neck cancer by reducing the dose to the healthy surrounding tissue, so called organs at risk (OARs), leading to a reduction in side effects.
Different treatment techniques for photon and particle (e.g. proton) therapy are compared for multiple tumour sites. Furthermore, tools for consistent contouring and dose prescription are presented in close collaboration with the European Particle Therapy Network (EPTN).
EPTN consensus-based guideline for the tolerance dose per fraction of organs at risk in the brain
EPTN consensus-based guideline for the tolerance dose per fraction of organs at risk in the brain
In collaboration with the European Particle Therapy Network, a consensus table of tolerance doses for Organs at Risk in the brain was created. These values were all defined as a near maximum EQD2 values. Using the linear quadratic formula the doses are recalculated depending on the number of fractions.
Please site this table as follows:
Eekers D, Lambrecht M, Nyström PDW, Swinnen A, Wesseling FWR, Roelofs E, Troost EG EPTN consensus-based guideline for the tolerance dose per fraction of organs at risk in the brain CancerData, 2018; doi:10.17195/candat.2018.01.1
EPTN International Neurological Contouring Atlas
Eekers et al. have published an international neurological atlas for contouring of organs at risk in consensus with the European Particle Therapy Network (EPTN). The purpose of this consensus atlas is to decrease inter- and intra-observer variability in delineating OARs relevant for neuro-oncology. We propose this atlas is used in photon and particle therapy in order to derive consistent dosimetric data. When required this atlas will be updated according to new insights.
Included are all OARs known to be relevant for radiation-induced toxicity in neuro-oncology: brain, brainstem, cochlea, vestibulum & semicircular canals, cornea, lens, retina, lacrimal gland, optic nerve, chiasm, pituitary, hippocampus and skin. A new OAR relevant for neuro-cognition, the posterior cerebellum is also included.
Three-dimensional delineation of the fifteen consensus OARs for neuro-oncology are shown on CT and 3 Tesla (3T) MR images (slice thickness 1 mm with intravenous contrast agent). All are presented in transversal, sagittal and coronal view.
Please cite this Atlas as follows:
Eekers D, In ’t Ven L, Roelofs E, Postma A, Troost EG. EPTN International Neurological Contouring Atlas CancerData, 2017. doi:10.17195/candat.2017.08.1
Persistent Identifiers with DOI
We're glad to announce that we have introduced persistent identifiers for our datasets using the DOI system. This offers persistent, semantically-interoperable resolution to CancerData research material. Furthermore, it simplifies and stimulates the re-use of valuable data for the community. One example is given here: doi:10.17195/candat.2015.10.5