Tumour hypoxia is associated with increased malignancy and poor prognosis. Recent data suggest that hypoxia gene-expression signatures have prognostic power. However, both tumour hypoxia and the biological adaptation to this stress are highly dynamic in space and time. Assessment of time-dependent gene-expression changes in response to hypoxia may thus provide additional biological insights an d help in prediction the impact of hypoxia on patient prognosis. Therefore, transcriptome profiling was performed for 3 cancer cell lines (DU145, HT29 and MCF7) after hypoxic exposure (0%) at 8 time-points (0, 1, 2, 4, 8, 12, 16 and 24 hours).
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