proton therapy

Optimization of Brain and Head & Neck Radiotherapy

Daniëlle BP Eekers

The aim of this thesis is to further optimise radiation therapy of Brain and Head & Neck cancer by reducing the dose to the healthy surrounding tissue, so called organs at risk (OARs), leading to a reduction in side effects.

Different treatment techniques for photon and particle (e.g. proton) therapy are compared for multiple tumour sites. Furthermore, tools for consistent contouring and dose prescription are presented in close collaboration with the European Particle Therapy Network (EPTN).

 

Development and evaluation of an online three-level proton vs photon decision support prototype for head and neck cancer – Comparison of dose, toxicity and cost-effectiveness

Qing Cheng, Erik Roelofs, Bram L.T. Ramaekers, Daniëlle Eekers, Johan van Soest, Tim Lustberg, Tim Hendriks, Frank Hoebers, Hans Paul van der Laan, Erik W. Korevaar, Andre Dekker, Johannes A. Langendijk, Philippe Lambin

Abstract

To quantitatively assess the effectiveness of proton therapy for individual patients, we developed a prototype for an online platform for proton decision support (PRODECIS) comparing photon and proton treatments on dose metric, toxicity and cost-effectiveness levels. An evaluation was performed with 23 head and neck cancer datasets.

 

PRODECIS system outline

Data from: Development and Evaluation of an Online Three-Level Proton vs Photon Decision Support Prototype for Head and Neck Cancer - Comparison of Dose, Toxicity and Cost-Effectiveness

Cheng Q, Roelofs E, Ramaekers B, et al. Data from: Development and Evaluation of an Online Three-Level Proton vs Photon Decision Support Prototype for Head and Neck Cancer - Comparison of Dose, Toxicity and Cost-Effectiveness. 2015. doi:10.17195/candat.2015.10.5.