@article {55, title = {PET-based dose painting in non-small cell lung cancer: Comparing uniform dose escalation with boosting hypoxic and metabolically active sub-volumes.}, journal = {Radiother Oncol}, volume = {116}, year = {2015}, month = {2015 Aug}, pages = {281-6}, abstract = {

BACKGROUND AND PURPOSE: We compared two imaging biomarkers for dose-escalation in patients with advanced non-small cell lung cancer (NSCLC). Treatment plans boosting metabolically active sub-volumes defined by FDG-PET or hypoxic sub-volumes defined by HX4-PET were compared with boosting the entire tumour.

MATERIALS AND METHODS: Ten NSCLC patients underwent FDG- and HX4-PET/CT scans prior to radiotherapy. Three isotoxic dose-escalation plans were compared per patient: plan A, boosting the primary tumour (PTVprim); plan B, boosting sub-volume with FDG >50\% SUVmax (PTVFDG); plan C, boosting hypoxic volume with HX4 tumour-to-background >1.4 (PTVHX4).

RESULTS: Average boost volumes were 507 {\textpm} 466 cm(3) for PTVprim, 173 {\textpm} 127 cm(3) for PTVFDG and 114 {\textpm} 73 cm(3) for PTVHX4. The smaller PTVHX4 overlapped on average 87 {\textpm} 16\% with PTVFDG. Prescribed dose was escalated to 87 {\textpm} 10 Gy for PTVprim, 107 {\textpm} 20 Gy for PTVFDG, and 117 {\textpm} 15 Gy for PTVHX4, with comparable doses to the relevant organs-at-risk (OAR). Treatment plans are available online (https://www.cancerdata.org/10.1016/j.radonc.2015.07.013).

CONCLUSIONS: Dose escalation based on metabolic sub-volumes, hypoxic sub-volumes and the entire tumour is feasible. Highest dose was achieved for hypoxia plans, without increasing dose to OAR. For most patients, boosting the metabolic sub-volume also resulted in boosting the hypoxic volume, although to a lower dose, but not vice versa.

}, keywords = {Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung, Cell Hypoxia, Female, Humans, Lung Neoplasms, Male, Middle Aged, Positron-Emission Tomography, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted}, issn = {1879-0887}, doi = {10.1016/j.radonc.2015.07.013}, author = {Even, Aniek J G and van der Stoep, Judith and Zegers, Catharina M L and Reymen, Bart and Troost, Esther G C and Lambin, Philippe and van Elmpt, Wouter} }